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KMID : 0613320120180010007
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Journal of the Korean Bone and Joint Tumor Soceity
2012 Volume.18 No. 1 p.7 ~ p.13
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Treatment of Squamous Cell Carcinoma in Extremity & Trunk
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Shin Duk-Seop
Kim Beom-Jung
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Abstract
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Purpose: The purpose of this study is to compare general survival rate and survival rate according to expectable prognostic factors by analyzing the result of treating a patient of squamous cell carcinoma.
Materials and Methods: From Mar. 1999 to Feb. 2011, 151 patients were pathologically confi rmed as squamous cell carcinoma of limbs and body in our hospital, and among those patients, 51 patients underwent the surgical treatment. This study included 41 patients who underwent the surgical treatment and were followed-up for more than 12 months. The mean age of population was 64.4 years. 31 males and 10 females were included. Wide excision with following skin grafts or fl aps for reconstruction (29 cases) was mostly performed, but amputation (12 cases) was also performed for cases with extremities where resection margin was diffi cultto obtain and cases with neural or vascular invasion. 8 patients underwent chemotherapy or radiotherapy after resection, and 33 underwent the operation only. Stages were classifi ed by AJCC Classifi cation, survival rate was calculated by Kaplan-Meier method and survival rate of groups was compared by Log-rank test. For the expectable prognostic factors related to survival rate, location of primary lesion, cause of disease, pathologic grade, staging, surgical method, additional anticancer therapy were examined and each survival rate was compared.
Results: The average follow-up period was 65.2 (12-132) months. Thirty patients survived out of 41 patients till last follow up. The overall survival rate in 5 years was 77%. Three cases (7.3%) had local recurrence, and 7 cases (17.0%) had metastasis. The average period of recurrence from operation was 27 (18-43) months. Possible prognostic factors such as location of primary lesion, cause of disease, pathologic grade, staging, additional anticancer therapy showed no signifi cant difference in survival rates. However, patients with amputation showed signifi cantly lower survival rate than those with wide excision.
Conclusion: In analysis the results of treating 41 cases of squamous cell carcinoma, the overall 5-year survival rate was 77%. And, among the several prognostic factors, only the surgical method was signifi cant statistically.
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KEYWORD
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squamous cell carcinoma, treatment method, survival rate, prognostic factor
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